After consuming cannabis, the cannabinoids and terpenes within the cannabis will react with the endocannabinoid system. The reaction of cannabinoids and terpenes within the endocannabinoid system may produce a synergistic combination of cannabinoids/terpenes (within the body) that are more potent than what they may produce on their own.
The entourage effect is also considered as a possible endocannabinoid system modulator.
An example of medicinal cannabis products that try to utilize this effect is full-spectrum CBD. Full-spectrum CBD contains low levels of other cannabinoids (and terpenes) that may have beneficial effects within the body when combined with the CBD cannabinoid.
Learn more:
https://cannabisinformationinstitute.com/what-is-the-entourage-effect-cannabinoids-terpenes-and-ecs/
The entourage effect could be the reason why different cannabis strains affect different individuals. Although the difference between Indica and Sativa cannabis strains should be considered, the cannabinoid content is, by far, the most important aspect of any cannabis strain.
Cannabinoids and terpenes can be found more often in some strains than others, however, these chemical compounds are not exclusive enough within Indica or Sativa strains to warrant the claims of certain effects only coming from Indicas or Sativas. The known effects of cannabis are caused by cannabinoids and terpenes, not by a specific strain classification.
Ethan Russo, one of the leading cannabis researchers in the world, argues, ” Given that such factors as plant height and leaflet width do not distinguish one Cannabis plant from another and similar difficulties in defining terms in Cannabis, the only reasonable solution is to characterize them by their biochemical/pharmacological characteristics”.
We also talked a little bit about this in episode 2 of the podcast 
Very interesting shit man! Zombie Nation and Green Beard both say cheeses have very little effect on them, but it smashes me up good lol.
Still amazes me what this plant does, and the effects it has on different people
"Keep away from people who try to belittle your ambitions. Small people always do that, but the really great make you feel that you, too, can become great.”
― Mark Twain
It’s crazy man, I may as well be smoking just tobacco when I have a cheese strain but my mate of floored just like Macky? it’s something I had never heard of before but defo something I’m going to have to research further. Thanks @canna_educator_ For all your info buddy?
If I have too much edibles I'll have a hoot and it levels me out. I suspect something entourage like is happening. I know others that this works for also, not what you'd think though, got too high = have some more. lol
We just smiled n waved sittn there on that sack o seeds
I think this is also why things like Sativex, or certain concentrates (isolates, terpene-less compounds, etc.) may not have the same effects/relief as something with the full spectrum of compounds.
@templegrower I fully agree with you there, especially with things like CBD isolate too. I was reading a study that involved people taking synthetic cannabinoids and most of them liked real cannabis a lot more, here's the study:
https://www.tandfonline.com/doi/abs/10.1080/02791072.2013.805976?journalCode=ujpd20
Some cannabis concentrates/extractions have a mix of different cannabinoids and terps and some people have theorized that some cannabis extractions encourage the entourage effect a lot more than consuming cannabis as a smokable or edible substance in flower form
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